Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease
نویسندگان
چکیده
منابع مشابه
Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease.
BACKGROUND Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone. In chronic kidney disease (CKD), circulating FGF-23 levels are markedly elevated and independently associated with mortality. Left ventricular hypertrophy and coronary artery calcification are potent risk factors for mortality in CKD, and FGFs have been implicated in the pathogenesis of both myocardial hypertrop...
متن کاملUpdate on Fibroblast Growth Factor 23 in Chronic Kidney Disease
Chronic kidney disease (CKD) is a public health epidemic that affects millions of people worldwide. Presence of CKD predisposes individuals to high risks of end-stage renal disease (ESRD), cardiovascular disease, and premature death. Disordered phosphate homeostasis with elevated circulating levels of fibroblast growth factor 23 (FGF23) is an early and pervasive complication of CKD. CKD is like...
متن کاملFibroblast growth factor 23/klotho axis in chronic kidney disease.
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates phosphate and 1,25-hydroxyvitamin D [1,25(OH)2D] metabolism. FGF23 binds to FGF receptor 1 with its coreceptor Klotho and maintains serum phosphate levels within the normal range by increasing renal phosphate excretion. In addition, FGF23 reduces the synthesis and accelerates the degradation of 1,25(OH)2D to reduce int...
متن کاملRegulation of fibroblast growth factor-23 in chronic kidney disease.
BACKGROUND Fibroblast growth factor-23 (FGF23) is a circulating factor that regulates the renal reabsorption of inorganic phosphate (Pi) and is increased in chronic kidney disease (CKD). The aim of the current investigation was to study the regulation of FGF23 in CKD subjects with various degree of renal function. As such, we analysed the relationship between FGF23, Pi, calcium, parathyriod hor...
متن کامل[Left ventricular hypertrophy in chronic kidney disease].
Chronic kidney disease (CKD) is associated with increased cardiovascular (CV) risk. Left ventricular (LV) hypertrophy (LVH), together with coronary artery disease, has been considered the main target of intervention. LVH is highly prevalent in CKD even in early stages, as compared to general non-selected population. This is mainly due to the multifactorial pathogenesis of LVH in renal patients ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2009
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.108.844506